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Naturally occurring antigens that are not perfectly suited for the use in diagnostic test systems, can be modified by means of genetic methods to obtain maximum effectiveness: The result is so-called designer antigens. The designer antigens are developed and produced in EUROIMMUN research laboratories. Compared to naturally occurring antigens, they offer many advantages:
- They are highly specific: Regions that may lead to undesired cross reactions are specifically switched off
- They are extremely sensitive: Antigen epitopes are multiplied, so that there are more binding sites for the antibodies
- They are customised explicitly for their application: Antibody binding sites of different antigens are combined into one fusion protein
Designer antigens are currently used in test systems for the diagnosis of the following diseases:
| Disease | Test system | Order number |
|---|---|---|
| Bullous pemphigoid | Anti-BP180-NC16A-4X ELISA | EA 1502-9601-2 G |
| Primary biliary cirrhosis | Anti-M2-3E-ELISA | EA 1622-9601 G |
| Wegener’s granulomatosis | Anti-PR3-hn-hr-ELISA | EA 1201-9601-2 G |
| Coeliac disease | Anti-Gliadin (GAF-3X)-ELISA | EV 3011-9601 G |
